25 resultados para Intestinos Inflamação Teses
em Universidade Federal do Rio Grande do Norte(UFRN)
Resumo:
VITULLO, Nadia Aurora Vanti. Avaliao do banco de dissertaes e teses da Associao Brasileira de Antropologia: uma anlise cienciomtrica. 2001. 143 f. Dissertaao (Mestrado) - Curso de Mestrado em Biblioteconomia e Cincia da Informao, Pontifcia Universidade Catlica de Campinas, Campinas, 2001.
Resumo:
OLIVEIRA, Raimundo Muniz de. Biblioteca digital de teses e dissertaoes: uma referencia fundamental. In: CINFORM ENCONTRO NACIONAL DE ENSINO E PESQUISA DA INFORMAAO,HUMANISMO E DESENVOLVIMENTO CIENTIFICO E TECNOLOGICO,7.,2007,Salvador. Anais...Salvador:UFBA, 2007.Disponivel em:www.cinform.ufba.br>. Acesso em: 27 set. 2007. Acesso em: 27 set. 2010.
Resumo:
CUNHA, Jacqueline de Arajo. Biblioteca Digital de Teses e Dissertaes: uma estratgia de preservao da memria cientfica. 2009. 141f. Dissertao (Mestrado)- Programa de Ps-Graduao em Cincia da Informao. Universidade Federal da Paraba, Joo Pessoa, 2009.
Resumo:
A pesquisa aborda o uso das Tecnologias de Informao e Comunicao, que vem revolucionando as atividades e ocasionando muitas mudanas relacionadas ao acesso e uso de informaes. O objetivo foi analisar o grau de utilizao do conhecimento cientfico produzido pelos Programas de Ps-Graduao das Universidades Pblicas Brasileiras, atravs da BDTD, pelos mestrandos dos referidos programas. Nos procedimentos metodolgicos realizados, procurou-se inicialmente analisar o amplo espectro da populao do corpus da pesquisa. Em razo da impossibilidade de trabalhar com os Programas de Ps-Graduao como um todo, optou-se por fazer um recorte, elegendo os cursos de Ps-Graduao em Cincia da Informao, vez que estes representam o principal segmento social de interesse da pesquisa. Foi utilizado o mtodo de estudo de usurios, onde se optou por adotar o grupo, estudos orientados aos usurios, que identifica as necessidades e comportamento de acesso e uso da informao. Para coletar os dados, elaborou-se um questionrio semi-estruturado com 25 questes, que versavam sobre o uso, dificuldades de acesso e recuperao da informao, bem como a satisfao na utilizao dessa fonte informacional. Dentre os vrios resultados obtidos, podemos destacar o fato de que a maioria dos mestrandos (71,8%) s teve contato com a BDTD somente no momento em que se encontrava cursando o mestrado e, somente 24,3%, tiveram contato durante a graduao. Estes resultados representam um problema, que pode afetar o bom desempenho do projeto BDTD, o qual consiste em disseminar e divulgar a produo cientfica dos Programas de Ps-Graduao das Universidades Pblicas Brasileiras para a sua comunidade. Foi observado tambm, que os mestrandos oriundos do curso de Biblioteconomia tende a ter contato com a BDTD bem mais cedo do que mestrandos de outros cursos de graduao. A fim de minimizar o problema detectado, prope-se uma divulgao mais eficaz na graduao atravs de dois procedimentos: Primeiro, o docente deve fazer uma divulgao mais eficaz da BDTD junto aos discentes de todos os cursos de graduao; segundo: dever ser feita a divulgao na mdia eletrnica, atravs da insero de cones da BDTD, nos portais dos Departamentos dos Cursos de Graduao das Universidades Pblicas Brasileiras. Acredita-se que com estes procedimentos seja possvel aperfeioar o uso dessa fonte de informao cientfica.
Bibliotecas digitais de teses e dissertaes brasileiras: paradigma do acesso livre informao cientfica
Resumo:
A evoluo da comunicao cientfica ao longo do tempo e o impacto causado pela A evoluo da comunicao cientfica ao longo do tempo e o impacto causado pela A evoluo da comunicao cientfica ao longo do tempo e o impacto causado pela se analisar as contribuies da Biblioteca Digital de Teses e Dissertaes (BDTD)para a comunicao cientfica atual, destacando possibilidades emergentes e desafios a serem superados. Apresenta uma breve evoluo da comunicao cientfica ao longo do tempo; discute os impactos causados pela Internet na comunicao, disponibilizao e acessibilidade de informaes tcnico-cientficas; e caracteriza BDTD destacando os desafios a serem superados. Dentre eles esto, a questo dos direitos autorais que ocasionam a baixa adeso dos autores ao projeto piloto do IBICT para disponibilizar teses e dissertaes no meio eletrnico. Para este desafio, so apontadas sugestes.
Resumo:
As bibliotecas de teses e dissertaes tm um papel fundamental para o desenvolvimento cientfico e cultural de um pas. Nesse sentido, buscou-se, de modo geral, analisar o panorama brasileiro das bibliotecas digitais de teses e dissertaes. Especificamente, objetivou-se caracterizar a sociedade da informao enquanto contexto das BDTD; caracterizar os vrios tipos de bibliotecas surgidos a partir da insero das novas tecnologias de informao e comunicao; identificar as diretrizes norteadoras da implantao de BDTD; e levantar as BDTD existentes no Brasil. Para tato, alm de levantamento bibliogrfico, realizou-se uma pesquisa nos sites de instituies de ensino superior brasileiras que j dispe de bibliotecas digitais de teses e dissertaes em funcionamento. A anlise e interpretao destes dados nos permite considerar que no Brasil as BDTD encontram-se num estgio embrionrio, sendo relevante pesquisar a histrica implantao e configurao desse novo modelo de biblioteca.
Resumo:
Galactans are polysaccharides sulfated present in the cell wall of red algae. Carrageenans are galactans well known in the food industry as gelling polysaccharides and for induce inflammatory process in rodents as animal model. The extraction of polysaccharides from A. multifida has been carried out by proteolysis and precipitation in different volumes of acetone, which produced three fractions (F1, F2, and FT). Chemical and physical analyses revealed that these fractions are sulfated galactan predominantly. Results of the antioxidant activity assays showed that all of these fractions have antioxidant activity and that was associated with sulfate content of the analysis of reducing power and total antioxidant capacity. However, these fractions were not effective against lipid peroxidation. The fraction FT presented higher activity on the APTT test at 200 μg (> 240 s). The assessment of the hemolytic activity showed that the FT fraction has the best activity, increasing lyses by the complement system to 42.3% (50 μg) (p< 0,001). The fraction FT showed the best yield, anticoagulant and hemolytic activity between the three fractions and therefore it was choose for the in vivo studies. The Inflammation assessment using the FT fraction (50 mg / kg MB) showed that the cellular migration and the IL-6 production increased 670.1% (p< 0,001) and 531.8% (p< 0,001), respectively. These results confirmed its use as an inflammation inducer in animal model. Cytotoxicity assay results showed that all fractions have toxic effects on 3T3 and HeLa cells after exposition of 48 hours, except when 100 μg for both F1 and FT were used. These results arise the discussion whether these polysaccharides it should be used as additive in foods, cosmetics and medicines.
Resumo:
Compounds derived from fungi has been the subject of many studies in order to broaden the knowledge of their bioactive potential. Polysaccharides from Caripia montagnei have been described to possess anti-inflammatory and antioxidant properties. In this study, glucans extracted from Caripia montagnei mushroom were chemically characterized and their effects evaluated at different doses and intervals of treatment. It was also described their action on colonic injury in the model of colitis induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS), and its action on cells of the human colon carcinoma (HT-29). Compounds extracted of C. montagnei contain high level of carbohydrates (96%), low content of phenolic compounds (1.5%) and low contamination with proteins (2.5%). The (FT-IR) and (NMR) analysis showed that polysaccharides from this species of mushroom are composed of α- and β-glucans. The colonic damage was evaluated by macroscopic, histological, biochemical and immunologic analyses. The results showed a reduction of colonic lesions in all groups treated with the glucans of Caripia montagnei (GCM). GCM significantly reduced the levels of IL-6 (50 and 75 mg/kg, p < 0.05), a major inflammatory cytokine. Biochemical analyses showed that such glucans acted on reducing levels of alkaline phosphatase (75 mg/kg, p < 0.01), nitric oxide (p < 0.001), and myeloperoxidase (p < 0.001). These results were confirmed microscopically by the reduction of cellular infiltration. The increase of catalase activity suggest a protective effect of GCM on colonic tissue, confirming their anti-inflammatory potential. GCM displayed cytostatic activity against HT-29 cells, causing accumulation of cells in G1 phase, blocking the cycle cell progression. Those glucans also showed ability to modulate the adhesion of HT-29 cells to Matrigel and reduced the oxidative stress. The antiproliferative activity against HT-29 cells displayed by GCM (p <0.001) can be attributed to its cytostatic activity and induction of apoptosis by GCM
Resumo:
The regulation of the inflammatory response is essential to maintain homeostasis. Several studies have been performed to search new drugs that can contribute to avoiding or minimizing an excessive inflammatory process. The aim of this study was to evaluate the effect of extracts of green algae Caulerpa mexican in models of inflammation. In mice, the model of peritonitis induced inflammatory zymosan pretreatment of mice with aqueous and methanol extracts of C. mexican was able to reduce cell migration to the peritoneal cavity. Treatment of mice with extracts of C. mexican also reduced the ear edema induced by xylene and exerted inhibitory action on the migration of leukocytes in inflammation-induced zymosan the air pouch, and timedependent for the extracts tested in the model of ulcerative colitis induced by DSS 3%, the extract methanol, but not the aqueous C. mexican, significantly reduced the clinical symptoms of colitis, as well as the production of proinflammatory cytokines in the culture of mouse colon, in the histological analysis there was a slight reduction of inflammation in the intestinal mucosa. We concluded that the administration of the extracts resulted in the reduction of cell migration to different sites as well as reducing the edema formation induced by chemical irritant. This study demonstrates for the first time the antiinflammatory effect of aqueous and methanolic extracts from green marine algae Caulerpa mexican
Resumo:
Alpha-lipoic acid (ALA) is a potent antioxidant with favourable anti-inflammatory, metabolic and endothelial effects, and has been widely investigated due to its potential against cardiovascular risk factors. This study aimed to evaluate the effect of oral ALA supplementation on oxidative stress biomarkers, inflammation and cardiovascular risk factors in patients with hypertension. This is a double-blind placebo-controlled randomized clinical trial, where the intervention was evaluated prospectively comparing results in both groups. The sample consisted of 64 hypertensive patients who were randomly distributed into ALA group (n = 32), receiving 600 mg / day ALA for twelve weeks and control group (n = 32), receiving placebo for the same period. The following parameters were evaluated before and after intervention: lipid peroxidation, content of reduced glutathione (GSH), enzymatic activities of glutathione peroxidase (GPx) and superoxide dismustase, ultrasensitive C-reactive protein (hs-CRP), triglycerides, total cholesterol and fractions, fasting glucose and anthropometric indicators. There was a statistically significant reduction (p <0.05) in serum concentrations of total cholesterol, very low density lipoprotein (VLDL), high density lipoprotein (HDL), triglycerides and blood glucose. There was a reduction in body weight and waist, abdominal and hip circumferences in the group that received ALA. In addition, there was a statistically significant increase (p <0.05) in the contents of reduced glutathione (GSH) and glutathione peroxidase (GPx) in the group receiving ALA. Oral administration of ALA appears to be a valuable adjuvant therapy, which may contribute to decrease the damage caused by oxidative stress and other risk factors associated with the atherosclerotic process
Resumo:
This work has the main purpose of conducting a survey of educational products present in dissertations and doctoral theses focused on the use of history in mathematics teaching and Didactics of mathematics with a French foundation produced in graduate programs in the strict sense of the Brazil between 1990 and 2010, the areas of Education, Mathematics Education, school of Natural Sciences and Mathematics and related areas, according to the research proposal of Mendes (2010). Our interest was to select the products that present concrete proposals for educational activities that can be used in the classroom of Basic Education and Training of Teachers of Mathematics. The research was implemented through a bibliographic study documents the Bank of dissertations and theses from CAPES, libraries and archives of some Postgraduate programs in the country who focus their studies on the subject object of this research, besides the Brazilian Digital Library Theses and Dissertations (BDBTD). From this survey we selected works that present educational products materialized in blocks of activities based on the use of teaching history of mathematics to the classroom as well as the sequence of activities based on the Teaching of Mathematics. In possession of material, produce a CD-ROM containing the selected activities, in order to help support the work of teachers regarding the use of these activities, as a supplementary material to textbooks in their math classes
Resumo:
Universidade Estadual do Rio Grande do Norte
Resumo:
This research aims to make a reflective analysis about the academic production originated in the stricto sensu post graduation programs in the country, produced in the period of 1990 to 2010, in the field of History of Mathematics, especifically on works about the History of Mathematics in Mathematics education and that present pedagogical proposals that make use of the History of Mathematics in order to teach Mathematics. Defending the thesis that the researches on mathematics education with goals turned to the use of didactic proposals related to the history of mathematic that take in consideration the coherency between epistemological aspects inherent to mathematics history and anthological elements materialized on the conceptions of mathematics and mathematics history and of apprenticeship (implicitly or explicitly exposed) may originate significant contribution to the field of history of mathematics on education. Among these, nine were Masters Degree dissertations and five PHDs theses. The reflective analysis was accomplished from two matrixes; one from theoretical nature and the other, ontologic nature, elaborated from the pretexts of Sanches Gamboa, about the epistemological analysis from academic production in the field of Mathematics Education and the following theoretical perspectives in the field of History of Mathematics Education, that are: linear evolutionary theory, structural construtivist operative, evolutionary discontinuous, historical and socialcultural investigation and the use of activities estimulating the usage of verbal and nonverbal expressions. These perspectives were based on the works of Miguel and Miorim, Mendes and Radford. As results, we have detected some established dissonances between the categories related to theoretical and ontologic levels and the pedagogical proposal presented in these researches. On the other hand, we have discovered works that are able to establish consonances between the theoretical and ontological elements and the presented pedagogical proposal. These works carry significative contributions to the field of History of Mathematics applied to Mathematics pedagogical practice, inclusively presenting significative theoretical elements to the production of knowledge recognized as scientific in the Mathematics field
Resumo:
Accidents caused by venomous animals represents a significant and serious public health problem in certain regions of Brazil, as well as in other parts of the world by the frequency with which they occur and the mortality they cause. The use of plant extracts as an antidote for poisoning cases is an ancient practice used in many communities that have no access to antivenom. Medicinal plants represent an important source of obtaining bioactive compounds able to assist directly in the treatment of poisoning or indirectly supplementing serum therapy currently used. The aim of this study was to evaluate the effect of extracts, fractions and isolated compounds from M. tenuiflora and H. speciosa in the inflammatory process induced by carrageenan and the venom of B. jararaca and T. serrulatus. The results showed that both M. tenuiflora and H. speciosa were capable of inhibiting cell migration and cytokines levels in peritonitis induced by carrageenin and venom of T. serrulatus. In poisoning by B. jararaca model, mice treated with the plants in studies decreased the leukocyte influx into the peritoneal cavity. Finally the M. tenuiflora and H. speciosa had antiphlogistic activity, reducing edema formation and exerted inhibitory action of leukocyte migration in local inflammation induced by the venom of B. jararaca. Through of Thin Layer Chromatography (TLC) analysis was possible identified the presence of flavonoids ,saponins and/or terpenes in aqueous extract of M. tenuiflora. By High Performance Liquid Chromatography analysis, it was possible to identify the presence of rutin and chlorogenic acid in aqueous extract of H. speciosa. We conclude that the administration of extracts, fractions and isolated compounds of H. speciosa and M. tenuiflora resulted in inhibition of the inflammatory process in different experimental models. This study demonstrates for the first time the effect of M. tenuiflora and H. speciosa in inhibition of the inflammation caused by B. jararaca and T. serrulatus venom.
Resumo:
O crescimento demogrfico de idosos um fenmeno mundial e exerce influncia sobre o desenvolvimento e funcionamento das sociedades. Fatores sociais, econmicos, ambientais, biolgicos e culturais influenciam o processo de envelhecimento, que pode vir acompanhado de contnua perda na capacidade de adaptao do indivduo ao meio ambiente, de maior vulnerabilidade ao estresse, limitaes funcionais e diminuio da qualidade de vida do indivduo. Todavia, ao longo do curso da vida, o indivduo vivencia mltiplas exposies adversas sade, e o declnio da mobilidade surge como um dos primeiros sinais do envelhecimento, repercutindo na sade fsica e mental do indivduo. Para contribuir com o conhecimento sobre os desfechos relacionados ao envelhecimento e mobilidade, o estudo IMIAS investiga idosos em quatro pases com diferentes perfis epidemiolgicos. O presente estudo abordou os possveis fatores associados ao declnio fsico em idosos de distintas sociedades, sobre a perspectiva epidemiolgica do curso da vida e dos biomarcadores da inflamação e do estresse. Objetivos: 1) Analisar as relaes entre as adversidades sociais e econmicas, vivenciadas durante a infncia, a fase adulta e a velhice, com o baixo desempenho fsico em populaes idosas, de diferentes contextos sociais, econmicos e culturais. 2) Verificar a associao entre os nveis elevados da protena c-reativa (PCR) com o desempenho fsico em idosos de diferentes populaes. 3) Avaliar se a desregulao nos nveis de cortisol diurno exerce influncia sobre o desempenho fsico em idosos com distintos perfis epidemiolgicos. Mtodos: Foram utilizados dados da linha de base do IMIAS Estudo Internacional de Mobilidade no Envelhecimento, composto por 1.995 indivduos entre 65 e 74 anos de idade, residentes em comunidades de quatro pases (Albnia, Brasil, Canad, Colmbia). O desempenho fsico foi avaliado atravs do Short Physical Performance Battery (SPPB) e da fora de preenso manual. As adversidades durante o curso da vida foram estimadas a partir de eventos e exposies sociais, econmicas e culturais ocorridas durante a infncia, fase adulta e velhice. Para avaliar o percurso biolgico e suas associaes com a mobilidade, a protena c-reativa e o cortisol foram considerados como biomarcadores da inflamação e do estresse, respectivamente. No sentido de responder as questes de investigaes, foram conduzidas anlises de estatstica descritiva, bivariada e multivariada, mediante tcnicas de distribuio de frequncias, teste qui-quadrado, odds ratio e regresses logstica, linear e multinvel. Resultados: O desempenho fsico foi menor nos participantes que vivem na Colmbia, Brasil e Albnia do que nos que vivem no Canad, mesmo quando ajustados por idade, sexo e adversidades durante o curso da vida. O baixo nvel de desempenho fsico (SPPB < 8) foi associado a ter sofrido adversidade social e econmica na infncia, ter tido ocupao semiqualificada na fase adulta, morar sozinho e possuir renda insuficiente na velhice. A PCR esteve associada com a baixa fora de preenso manual e com o SPPB<8. Entretanto, a associao entre a PCR e a fora de preenso manual no se manteve quando ajustada por fatores socioeconmicos e hbitos de sade. As associaes negativas entre SPPB e PCR permaneceram significativas mesmo aps ajustes por idade, sexo, escolaridade, local de pesquisa e condies de sade. O baixo desempenho fsico (SPPB 8) foi associado com uma significativa diminuio nos nveis de cortisol ao acordar, em comparao com os nveis de cortisol de idosos com bom desempenho fsico (SPPB > 8), mesmo aps modelos controlados por local de estudo, sexo, depresso, hbitos de sade, uso de psicotrpicos e ndice de massa corporal. Concluses: Os resultados evidenciaram associao entre a inflamação, o estresse e as desigualdades sociais e econmicas na infncia, sobre o desempenho fsico de idosos com diferenciados perfis epidemiolgicos. Enfatizamos que a promoo do envelhecimento saudvel requer considerar polticas e prticas que favoream o bem-estar econmico e social para crianas, adultos e idosos.
